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The management of tuberculosis (TB) in people with medical co-morbidities, substance-use disorders, advanced age or pregnancy is challenging; consultation with a TB expert is recommended.
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Adverse events and treatment interruption are more common in these special populations; close monitoring and additional support is often needed.
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Given alterations in TB-drug pharmacokinetics and the potential for severe drug-drug interactions in patients with medical co-morbidities, we recommend consultation with an experienced pharmacist.
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TB disease and its treatment have important implications for the management of co-morbid conditions; close collaboration with medical specialists and allied health professionals is often required.
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The prolonged course of TB treatment is a useful opportunity to screen for co-morbidity and to facilitate referral and linkage into care.
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