TB Manual

• Mono-resistant TB is defined as resistance to only 1 of the 4 first-line drugs.

• Polydrug-resistant TB is defined as resistance to at least two first-line drugs without resistance to RMP.

• MDR-TB is defined as TB due to bacteria resistant to isoniazid and rifampin with or without resistance to other first line anti-TB drugs.

• Extensively-drug-resistant TB (XDR-TB) is now, after being updated,⁵ divided into: Pre-XDR-TB, which is now defined as MDR-TB with additional resistance to any fluoroquinolone; and XDR-TB, which is defined as pre-XDR-TB with additional resistance to bedaquiline or linezolid.

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