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Other considerations |
Effect/Impact |
Effect on Recommendation (potentially can increase to strong, or decrease to conditional) |
| Relative importance of the outcomes | “Critical” (eg, death, cure, failure)
“Not critical” (eg, Intolerance, Inconvenience) |
Strengthen
Weaken |
| Magnitude of the effect and/or difference | Large effect or difference
Small or no effect or difference |
Strengthen
Weaken |
| Balance of benefits and harms | Benefits clearly outweigh harms (eg, substantial benefit, but minimal harms)
Closely balanced benefits and harms (eg, substantial benefit, but also substantial harms) |
Strengthen “For” (If harms outweigh benefits would strengthen “Against”)
Weaken |
| Patient values and preferences | Judged very likely that patients would prefer intervention
Judged very likely that patients would not prefer intervention |
Strengthen “For” (Weaken “Against”)
Strengthen “Against” |
| Cost – Resource Use | Low cost, cost saving compared to alternative, cost-effective Strengthen High cost, higher cost than alternative, not cost-effective |
Weaken
Strengthen |
| Implementability | Difficult to implement | Weaken |
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